5HTB

Crystal structure of haspin (GSG2) in complex with bisubstrate inhibitor ARC-3353

Summary for 5HTB

Entry DOI	10.2210/pdb5htb/pdb
Descriptor	Serine/threonine-protein kinase haspin, ARC-3353 inhibitor, (4R)-2-METHYLPENTANE-2,4-DIOL, ... (8 entities in total)
Functional Keywords	transferase, kinase, inhibitor, allosteric, structural genomics consortium (sgc), transferase-transferase inhibitor complex, bisubstrate inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: Q8TF76
Total number of polymer chains	2
Total formula weight	42360.40
Authors	Chaikuad, A.,Heroven, C.,Lavogina, D.,Kestav, K.,Uri, A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2016-01-26, release date: 2016-05-11, Last modification date: 2023-04-26)
Primary citation	Lavogina, D.,Kestav, K.,Chaikuad, A.,Heroven, C.,Knapp, S.,Uri, A. Co-crystal structures of the protein kinase haspin with bisubstrate inhibitors. Acta Crystallogr.,Sect.F, 72:339-345, 2016 Cited by PubMed: 27139824 DOI: 10.1107/S2053230X16004611 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation