5HQ3
Stable, high-expression variant of human acetylcholinesterase
Summary for 5HQ3
Entry DOI | 10.2210/pdb5hq3/pdb |
Descriptor | Acetylcholinesterase, O-ETHYLMETHYLPHOSPHONIC ACID ESTER GROUP, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total) |
Functional Keywords | design, de novo protein, hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell junction, synapse . Isoform T: Nucleus. Isoform H: Cell membrane ; Lipid-anchor, GPI-anchor ; Extracellular side : P22303 P22303 |
Total number of polymer chains | 2 |
Total formula weight | 123155.34 |
Authors | Goldenzweig, A.,Goldsmith, M.,Hill, S.E.,Gertman, O.,Laurino, P.,Ashani, Y.,Dym, O.,Albeck, S.,Unger, T.,Prilusky, J.,Lieberman, R.L.,Aharoni, A.,Silman, I.,Sussman, J.L.,Tawfik, D.S.,Fleishman, S.J. (deposition date: 2016-01-21, release date: 2016-07-27, Last modification date: 2024-01-10) |
Primary citation | Goldenzweig, A.,Goldsmith, M.,Hill, S.E.,Gertman, O.,Laurino, P.,Ashani, Y.,Dym, O.,Unger, T.,Albeck, S.,Prilusky, J.,Lieberman, R.L.,Aharoni, A.,Silman, I.,Sussman, J.L.,Tawfik, D.S.,Fleishman, S.J. Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability. Mol.Cell, 63:337-346, 2016 Cited by PubMed: 27425410DOI: 10.1016/j.molcel.2016.06.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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