5HPU

Insulin with proline analog HyP at position B28 in the R6 state

Summary for 5HPU

Entry DOI	10.2210/pdb5hpu/pdb
Related	5HPR
Descriptor	Insulin, chain A, Insulin, chain B, PHENOL, ... (6 entities in total)
Functional Keywords	insulin, non-canonical amino acid, hydroxyproline, non-natural amino acid, unnatural amino acid, hormone
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	12057.25
Authors	Lieblich, S.A.,Fang, K.Y.,Cahn, J.K.B.,Tirrell, D.A. (deposition date: 2016-01-21, release date: 2017-01-25, Last modification date: 2023-09-27)
Primary citation	Lieblich, S.A.,Fang, K.Y.,Cahn, J.K.B.,Rawson, J.,LeBon, J.,Ku, H.T.,Tirrell, D.A. 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation. J. Am. Chem. Soc., 139:8384-8387, 2017 Cited by PubMed: 28598606 DOI: 10.1021/jacs.7b00794 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation