5HP3

Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA sequence derived from S. cerevisiae BDF2 gene with AC mismatch at reaction site

Summary for 5HP3

• Entry DOI: 10.2210/pdb5hp3/pdb
• Related: 5ED1 5ED2 5HP2
• Descriptor: Double-stranded RNA-specific editase 1, RNA (5'-R(*UP*UP*CP*CP*CP*CP*AP*CP*AP*UP*UP*(8AZ)P*GP*AP*CP*GP*UP*UP*CP*AP*GP*UP*C)-3'), RNA (5'-R(*GP*AP*CP*UP*GP*AP*AP*CP*GP*AP*CP*CP*AP*AP*UP*GP*UP*GP*GP*GP*GP*AP*A)-3'), ... (6 entities in total)
• Functional Keywords: deaminase, human, hydrolase-rna complex, hydrolase/rna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 106176.51

Authors

Matthews, M.M.,Fisher, A.J.,Beal, P.A. (deposition date: 2016-01-20, release date: 2016-04-13, Last modification date: 2023-09-27)

• Primary citation: Matthews, M.M.,Thomas, J.M.,Zheng, Y.,Tran, K.,Phelps, K.J.,Scott, A.I.,Havel, J.,Fisher, A.J.,Beal, P.A.; Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.; Nat.Struct.Mol.Biol., 23:426-433, 2016; PubMed: 27065196; DOI: 10.1038/nsmb.3203

Experimental method

X-RAY DIFFRACTION (3.091 Å)