5HOT

Structural Basis for Inhibitor-Induced Aggregation of HIV-1 Integrase

Summary for 5HOT

Entry DOI	10.2210/pdb5hot/pdb
Related	5HRN 5HRP 5HRR 5HRS
Descriptor	Integrase, (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid (2 entities in total)
Functional Keywords	integrase, inhibitor complex, nucleic acid binding, dna integration, transferase-inhibitor complex, transferase/inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	65987.17
Authors	Gupta, K.,Turkki, V.,Sherrill-Mix, S.,Hwang, Y.,Eilers, G.,Taylor, L.,McDanal, C.,Wang, P.,Temelkoff, D.,Nolte, R.,Velthuisen, E.,Jeffrey, J.,Van Duyne, G.D.,Bushman, F.D. (deposition date: 2016-01-19, release date: 2016-12-14, Last modification date: 2023-09-27)
Primary citation	Gupta, K.,Turkki, V.,Sherrill-Mix, S.,Hwang, Y.,Eilers, G.,Taylor, L.,McDanal, C.,Wang, P.,Temelkoff, D.,Nolte, R.T.,Velthuisen, E.,Jeffrey, J.,Van Duyne, G.D.,Bushman, F.D. Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol., 14:e1002584-e1002584, 2016 Cited by PubMed: 27935939 DOI: 10.1371/journal.pbio.1002584 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4.4 Å)

Structure validation