5HO8

DISCOVERY OF NOVEL 7-AZAINDOLES AS PDK1 INHIBITORS

Summary for 5HO8

Entry DOI	10.2210/pdb5ho8/pdb
Descriptor	3-phosphoinositide-dependent protein kinase 1, 4-butyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine, SULFATE ION, ... (4 entities in total)
Functional Keywords	pdk1 inhibitor, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: O15530
Total number of polymer chains	1
Total formula weight	36079.19
Authors	Wucherer-Plietker, M.,Esdar, C.,Knoechel, T.,Hillertz, P.,Heinrich, T.,Buchstaller, H.P.,Greiner, H.,Dorsch, D.,Calderini, M.,Bruge, D.,Mueller, T.J.J.,Graedler, U. (deposition date: 2016-01-19, release date: 2016-06-08, Last modification date: 2024-01-10)
Primary citation	Wucherer-Plietker, M.,Merkul, E.,Muller, T.J.,Esdar, C.,Knochel, T.,Heinrich, T.,Buchstaller, H.P.,Greiner, H.,Dorsch, D.,Finsinger, D.,Calderini, M.,Bruge, D.,Gradler, U. Discovery of novel 7-azaindoles as PDK1 inhibitors. Bioorg.Med.Chem.Lett., 26:3073-3080, 2016 Cited by PubMed: 27217002 DOI: 10.1016/j.bmcl.2016.05.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation