5HDB

Integrin alphaIIbbeta3 in complex with Ro-435054

Replaces:  4Z7S

Summary for 5HDB

• Entry DOI: 10.2210/pdb5hdb/pdb
• Related PRD ID: PRD_002217
• Descriptor: Integrin alpha-IIb, CALCIUM ION, MAGNESIUM ION, ... (15 entities in total)
• Functional Keywords: cell adhesion, platelet aggregation, membrane protein-immune system complex, integrin inhibitor, rgd mimetics, membrane protein/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 301439.38

Authors

Lin, F.Y. (deposition date: 2016-01-05, release date: 2016-02-03, Last modification date: 2020-07-29)

• Primary citation: Lin, F.Y.,Zhu, J.,Eng, E.T.,Hudson, N.E.,Springer, T.A.; beta-Subunit Binding Is Sufficient for Ligands to Open the Integrin alpha IIb beta 3 Headpiece.; J.Biol.Chem., 291:4537-4546, 2016; PubMed: 26631735; DOI: 10.1074/jbc.M115.705624

Experimental method

X-RAY DIFFRACTION (2.7012 Å)