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5HCZ

EGFR kinase domain mutant "TMLR" with 3-azetidinyl azaindazole compound 21

Summary for 5HCZ
Entry DOI10.2210/pdb5hcz/pdb
Related5HCX 5HCY
DescriptorEpidermal growth factor receptor, SULFATE ION, 2-[1-[1-[(2~{S})-butan-2-yl]-6-[[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]amino]pyrazolo[4,3-c]pyridin-3-yl]azetidin-3-yl]propan-2-ol, ... (4 entities in total)
Functional Keywordsprotein kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains1
Total formula weight38197.13
Authors
Eigenbrot, C.,Yu, C. (deposition date: 2016-01-04, release date: 2016-09-07, Last modification date: 2023-09-27)
Primary citationChan, B.K.,Hanan, E.J.,Bowman, K.K.,Bryan, M.C.,Burdick, D.,Chan, E.,Chen, Y.,Clausen, S.,Dela Vega, T.,Dotson, J.,Eigenbrot, C.,Elliott, R.L.,Heald, R.A.,Jackson, P.S.,Knight, J.D.,La, H.,Lainchbury, M.D.,Malek, S.,Purkey, H.E.,Schaefer, G.,Schmidt, S.,Seward, E.M.,Sideris, S.,Shao, L.,Wang, S.,Yeap, S.K.,Yen, I.,Yu, C.,Heffron, T.P.
Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor.
J.Med.Chem., 59:9080-9093, 2016
Cited by
PubMed: 27564586
DOI: 10.1021/acs.jmedchem.6b00995
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.62 Å)
Structure validation

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