5H8O

Crystal structure of an ASC-binding nanobody in complex with the CARD domain of ASC

Summary for 5H8O

• Entry DOI: 10.2210/pdb5h8o/pdb
• Related: 5H8D
• Descriptor: VHH nanobody, Apoptosis-associated speck-like protein containing a CARD (2 entities in total)
• Functional Keywords: vhh nanobody, asc-binding, antibody fragment, inflammasome, immune system
• Biological source: Lama glama (llama); More
• Cellular location: Cytoplasm: Q9ULZ3
• Total number of polymer chains: 2
• Total formula weight: 21717.33

Authors

Lu, A.,Schmidt, F.I.,Ruan, J.,Tang, C.,Wu, H.,Ploegh, H.L. (deposition date: 2015-12-23, release date: 2016-04-06, Last modification date: 2016-05-18)

• Primary citation: Schmidt, F.I.,Lu, A.,Chen, J.W.,Ruan, J.,Tang, C.,Wu, H.,Ploegh, H.L.; A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.; J.Exp.Med., 213:771-790, 2016; PubMed: 27069117; DOI: 10.1084/jem.20151790

Experimental method

X-RAY DIFFRACTION (4.206 Å)