5H82

HETEROYOHIMBINE SYNTHASE THAS2 FROM CATHARANTHUS ROSEUS - APO FORM

Summary for 5H82

• Entry DOI: 10.2210/pdb5h82/pdb
• Descriptor: heteroyohimbine synthase THAS2, ZINC ION (3 entities in total)
• Functional Keywords: heteroyohimbine synthase, medium chain dehydrogenase/reductase, nadp+ dependent enzyme, zinc binding site, oxidoreductase
• Biological source: Catharanthus roseus (Madagascar periwinkle)
• Total number of polymer chains: 2
• Total formula weight: 85499.35

Authors

Stavrinides, A.,Tatsis, E.C.,Caputi, L.,Foureau, E.,Stevenson, C.E.M.,Lawson, D.M.,Courdavault, V.,O'Connor, S.E. (deposition date: 2015-12-23, release date: 2016-07-27, Last modification date: 2024-01-10)

• Primary citation: Stavrinides, A.,Tatsis, E.C.,Caputi, L.,Foureau, E.,Stevenson, C.E.,Lawson, D.M.,Courdavault, V.,O'Connor, S.E.; Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity.; Nat Commun, 7:12116-12116, 2016; PubMed: 27418042; DOI: 10.1038/ncomms12116

Experimental method

X-RAY DIFFRACTION (2.05 Å)