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5H6Q

Crystal structure of LSD1-CoREST in complex with peptide 11

Summary for 5H6Q
Entry DOI10.2210/pdb5h6q/pdb
DescriptorLysine-specific histone demethylase 1A, REST corepressor 1, peptide SRTMQTARKSTGGKAPRKQLK, ... (6 entities in total)
Functional Keywordsdemethylase, amine oxidase, chromatin, histone, fad, corepressor, oxidoreductase-transcription-inhibitor complex, oxidoreductase/transcription/inhibitor
Biological sourceHomo sapiens (Human)
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Cellular locationNucleus : O60341 Q9UKL0
Total number of polymer chains3
Total formula weight93675.66
Authors
Kikuchi, M.,Amano, Y.,Sato, S.,Yokoyama, S.,Umezawa, N.,Higuchi, T.,Umehara, T. (deposition date: 2016-11-14, release date: 2017-04-12, Last modification date: 2023-11-08)
Primary citationAmano, Y.,Kikuchi, M.,Sato, S.,Yokoyama, S.,Umehara, T.,Umezawa, N.,Higuchi, T.
Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1.
Bioorg. Med. Chem., 25:2617-2624, 2017
Cited by
PubMed: 28336409
DOI: 10.1016/j.bmc.2017.03.016
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.53 Å)
Structure validation

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