5GTY

Crystal structure of EGFR 696-1022 T790M in complex with LXX-6-26

Summary for 5GTY

• Entry DOI: 10.2210/pdb5gty/pdb
• Related: 5GMP 5GNK 5GTZ
• Descriptor: Epidermal growth factor receptor, 1-[(3R)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: egfr, t790m, lxx-6-26, inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 8
• Total formula weight: 305484.92

Authors

Yan, X.E.,Yun, C.H. (deposition date: 2016-08-23, release date: 2017-09-06, Last modification date: 2023-11-08)

• Primary citation: Hu, C.,Wang, A.,Wu, H.,Qi, Z.,Li, X.,Yan, X.E.,Chen, C.,Yu, K.,Zou, F.,Wang, W.,Wang, W.,Wu, J.,Liu, J.,Wang, B.,Wang, L.,Ren, T.,Zhang, S.,Yun, C.H.,Liu, J.,Liu, Q.; Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode.; Oncotarget, 8:18359-18372, 2017; PubMed: 28407693; DOI: 10.18632/oncotarget.15443

Experimental method

X-RAY DIFFRACTION (3.14 Å)