5GDS

HIRUNORMS ARE TRUE HIRUDIN MIMETICS. THE CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN:HIRUNORM V COMPLEX

Summary for 5GDS

Entry DOI	10.2210/pdb5gds/pdb
Descriptor	ALPHA-THROMBIN, HIRUNORM V, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	serine protease-inhibitor complex, thrombin, thrombin synthetic inhibitors, antithrombotics, hirunorms, hirudin-like binding mode, blood coagulation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	37056.17
Authors	De Simone, G.,Lombardi, A.,Galdiero, S.,Nastri, F.,Della Morte, R.,Staiano, N.,Pedone, C.,Bolognesi, M.,Pavone, V. (deposition date: 1997-07-17, release date: 1998-01-21, Last modification date: 2023-08-09)
Primary citation	De Simone, G.,Lombardi, A.,Galdiero, S.,Nastri, F.,Della Morte, R.,Staiano, N.,Pedone, C.,Bolognesi, M.,Pavone, V. Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex. Protein Sci., 7:243-253, 1998 Cited by PubMed: 9521099 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation