5FYK

Crystal Structure at 3.7 A Resolution of Fully Glycosylated HIV-1 Clade B JR-FL SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122, 35O22 and VRC01

Summary for 5FYK

• Entry DOI: 10.2210/pdb5fyk/pdb
• Related: 5FYJ 5FYL
• Descriptor: JR-FL, GP41 ENV ECTODOMAIN, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (24 entities in total)
• Functional Keywords: viral protein, hiv, envelope, glycan, trimer
• Biological source: HUMAN IMMUNODEFICIENCY VIRUS 1; More
• Total number of polymer chains: 8
• Total formula weight: 246324.72

Authors

Stewart-Jones, G.B.E.,Zhou, T.,Thomas, P.V.,Kwong, P.D. (deposition date: 2016-03-08, release date: 2016-04-27, Last modification date: 2024-01-10)

• Primary citation: Stewart-Jones, G.B.E.,Soto, C.,Lemmin, T.,Chuang, G.Y.,Druz, A.,Kong, R.,Thomas, P.V.,Wagh, K.,Zhou, T.,Behrens, A.J.,Bylund, T.,Choi, C.W.,Davison, J.R.,Georgiev, I.S.,Joyce, M.G.,Kwon, Y.D.,Pancera, M.,Taft, J.,Yang, Y.,Zhang, B.,Shivatare, S.S.,Shivatare, V.S.,Lee, C.C.D.,Wu, C.Y.,Bewley, C.A.,Burton, D.R.,Koff, W.C.,Connors, M.,Crispin, M.,Korber, B.T.,Wong, C.H.,Mascola, J.R.,Kwong, P.D.; Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G; Cell(Cambridge,Mass.), 165:813-, 2016; PubMed: 27114034; DOI: 10.1016/J.CELL.2016.04.010

Experimental method

X-RAY DIFFRACTION (3.107 Å)