5FWW

Wnt modulator Kremen in complex with DKK1 (CRD2) and LRP6 (PE3PE4)

Summary for 5FWW

Entry DOI	10.2210/pdb5fww/pdb
Related	5FWS 5FWT 5FWU 5FWV
Descriptor	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6, KREMEN PROTEIN 1, DICKKOPF-RELATED PROTEIN 1, ... (4 entities in total)
Functional Keywords	signaling protein, wnt, cell surface, signalling, membrane protein
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Cell membrane ; Single-pass type I membrane protein: O75581 Membrane ; Single-pass type I membrane protein : Q96MU8 Secreted: O94907
Total number of polymer chains	3
Total formula weight	112469.58
Authors	Zebisch, M.,Jackson, V.A.,Jones, E.Y. (deposition date: 2016-02-21, release date: 2016-07-20, Last modification date: 2016-09-28)
Primary citation	Zebisch, M.,Jackson, V.A.,Zhao, Y.,Jones, E.Y. Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight Into Ternary Complex Formation with Lrp6 and Dickkopf Structure, 24:1599-, 2016 Cited by PubMed: 27524201 DOI: 10.1016/J.STR.2016.06.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation