5FUQ

CRYSTAL STRUCTURE OF THE H80R VARIANT OF NQO1 BOUND TO DICOUMAROL

Summary for 5FUQ

Entry DOI	10.2210/pdb5fuq/pdb
Descriptor	NAD(P)H DEHYDROGENASE [QUINONE] 1, FLAVIN-ADENINE DINUCLEOTIDE, BISHYDROXY[2H-1-BENZOPYRAN-2-ONE,1,2-BENZOPYRONE], ... (5 entities in total)
Functional Keywords	oxidoreductase, nadph-quinone oxidoreductase 1, nqo1, fad, dicoumarol
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: P15559
Total number of polymer chains	2
Total formula weight	64669.48
Authors	Gavira, J.A.,Medina-Carmona, E.,Pey, A.L. (deposition date: 2016-01-29, release date: 2017-02-22, Last modification date: 2024-01-10)
Primary citation	Medina-Carmona, E.,Fuchs, J.E.,Gavira, J.A.,Mesa-Torres, N.,Neira, J.L.,Salido, E.,Palomino-Morales, R.,Burgos, M.,Timson, D.J.,Pey, A.L. Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution. Hum.Mol.Genet., 26:3531-3544, 2017 Cited by PubMed: 28911204 DOI: 10.1093/hmg/ddx238 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.04 Å)

Structure validation