5FQR

Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 2.

Summary for 5FQR

• Entry DOI: 10.2210/pdb5fqr/pdb
• Related: 5FQP 5FQS 5FQT 5FQV
• Descriptor: ESTROGEN RECEPTOR, (E)-3-[4-[(1R)-6-HYDROXY-2-ISOBUTYL-3,4-DIHYDRO-1H-ISOQUINOLIN-1-YL]PHENYL]PROP-2-ENOIC ACID (3 entities in total)
• Functional Keywords: signaling protein, breast cancer, estrogen receptor downregulator, fulvestrant, thiq, nuclear hormone receptor
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
• Total number of polymer chains: 1
• Total formula weight: 28593.49

Authors

Scott, J.S.,bailey, A.,Davies, R.D.M.,Degorce, S.L.,MacFaul, P.A.,Gingell, H.,Moss, T.,Norman, R.A.,Pink, J.H.,Rabow, A.A.,Roberts, B.,Smith, P.D. (deposition date: 2015-12-14, release date: 2016-02-10, Last modification date: 2016-10-12)

• Primary citation: Scott, J.S.,Bailey, A.,Davies, R.D.,Degorce, S.L.,Macfaul, P.A.,Gingell, H.,Moss, T.,Norman, R.A.,Pink, J.H.,Rabow, A.A.,Roberts, B.,Smith, P.D.; Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat.; Acs Med.Chem.Lett., 7:94-, 2016; PubMed: 26819673; DOI: 10.1021/ACSMEDCHEMLETT.5B00413

Experimental method

X-RAY DIFFRACTION (1.88 Å)