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5FPV

Crystal structure of human JMJD2A in complex with compound KDOAM20A

Summary for 5FPV
Entry DOI10.2210/pdb5fpv/pdb
Related5FPL 5FPU
DescriptorLYSINE-SPECIFIC DEMETHYLASE 4A, MANGANESE (II) ION, 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, ... (6 entities in total)
Functional Keywordsoxidoreductase, jmjd2a, kdm4a
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus : O75164
Total number of polymer chains8
Total formula weight339130.99
Authors
Srikannathasan, V.,Gileadi, C.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Oppermann, U. (deposition date: 2015-12-03, release date: 2016-01-13, Last modification date: 2024-01-10)
Primary citationJohansson, C.,Velupillai, S.,Tumber, A.,Szykowska, A.,Hookway, E.S.,Nowak, R.P.,Strain-Damerell, C.,Gileadi, C.,Philpott, M.,Burgess-Brown, N.,Wu, N.,Kopec, J.,Nuzzi, A.,Steuber, H.,Egner, U.,Badock, V.,Munro, S.,Lathangue, N.B.,Westaway, S.,Brown, J.,Athanasou, N.,Prinjha, R.,Brennan, P.E.,Oppermann, U.
Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12:539-, 2016
Cited by
PubMed: 27214403
DOI: 10.1038/NCHEMBIO.2087
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.44 Å)
Structure validation

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