5FOB

Crystal Structure of Human Complement C3b in complex with Smallpox Inhibitor of Complement (SPICE)

Summary for 5FOB

• Entry DOI: 10.2210/pdb5fob/pdb
• Related: 5FO7 5FO8 5FO9 5FOA
• Descriptor: COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, SMALLPOX INHIBITOR OF COMPLEMENT SPICE, D15L, ... (10 entities in total)
• Functional Keywords: lipid binding protein, complement system, immune system, plasma protein, regulators of complement activity, cofactor activity, decay accelerating activity, immune evasion
• Biological source: VARIOLA MAJOR VIRUS; More
• Cellular location: Secreted: P01024 Q76U65
• Total number of polymer chains: 3
• Total formula weight: 206814.60

Authors

Forneris, F.,Wu, J.,Xue, X.,Gros, P. (deposition date: 2015-11-18, release date: 2016-04-06, Last modification date: 2024-01-10)

• Primary citation: Forneris, F.,Wu, J.,Xue, X.,Ricklin, D.,Lin, Z.,Sfyroera, G.,Tzekou, A.,Volokhina, E.,Granneman, J.C.,Hauhart, R.,Bertram, P.,Liszewski, M.K.,Atkinson, J.P.,Lambris, J.D.,Gros, P.; Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.; Embo J., 35:1133-, 2016; PubMed: 27013439; DOI: 10.15252/EMBJ.201593673

Experimental method

X-RAY DIFFRACTION (2.6 Å)