5FLF

DISEASE LINKED MUTATION IN FGFR

Summary for 5FLF

Entry DOI	10.2210/pdb5flf/pdb
Descriptor	FIBROBLAST GROWTH FACTOR RECEPTOR 1, SULFATE ION, ACETATE ION, ... (6 entities in total)
Functional Keywords	transferase, auto-activating, cancer, growth factor, receptor, mutation;
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cell membrane; Single-pass type I membrane protein: P11362
Total number of polymer chains	5
Total formula weight	177743.93
Authors	Thiyagarajan, N.,Bunney, T.D.,Katan, M. (deposition date: 2015-10-26, release date: 2016-03-30, Last modification date: 2024-01-10)
Primary citation	Patani, H.,Bunney, T.D.,Thiyagarajan, N.,Norman, R.A.,Ogg, D.,Breed, J.,Ashford, P.,Potterton, A.,Edwards, M.,Williams, S.V.,Thomson, G.S.,Pang, C.S.,Knowles, M.A.,Breeze, A.L.,Orengo, C.,Phillips, C.,Katan, M. Landscape of Activating Cancer Mutations in Fgfr Kinases and Their Differential Responses to Inhibitors in Clinical Use. Oncotarget, 7:24252-, 2016 Cited by PubMed: 26992226 DOI: 10.18632/ONCOTARGET.8132 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.58 Å)

Structure validation