5FI7

Crystal structure of human GAC in complex with inhibitor UPGL_00015: 2-phenyl-~{N}-[5-[(3~{S})-3-[[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]oxy]pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl]ethanamide

Summary for 5FI7

Entry DOI	10.2210/pdb5fi7/pdb
Related	5FI2 5FI6
Descriptor	Glutaminase kidney isoform, mitochondrial, 2-phenyl-~{N}-[5-[(3~{S})-3-[[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]oxy]pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl]ethanamide (3 entities in total)
Functional Keywords	glutaminase c, complex, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	238873.59
Authors	Huang, Q.,Cerione, R. (deposition date: 2015-12-22, release date: 2016-05-11, Last modification date: 2023-09-27)
Primary citation	McDermott, L.A.,Iyer, P.,Vernetti, L.,Rimer, S.,Sun, J.,Boby, M.,Yang, T.,Fioravanti, M.,O'Neill, J.,Wang, L.,Drakes, D.,Katt, W.,Huang, Q.,Cerione, R. Design and evaluation of novel glutaminase inhibitors. Bioorg.Med.Chem., 24:1819-1839, 2016 Cited by PubMed: 26988803 DOI: 10.1016/j.bmc.2016.03.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation