5FE3
Crystal structure of human PCAF bromodomain in complex with fragment MB360 (fragment 4)
Summary for 5FE3
| Entry DOI | 10.2210/pdb5fe3/pdb |
| Descriptor | Histone acetyltransferase KAT2B, 1,2-ETHANEDIOL, 4-methoxy-1,2-benzoxazol-3-amine, ... (4 entities in total) |
| Functional Keywords | signaling protein, bromodomain, histone acetyltransferase kat2b, histone, acetylation, acetyllysine, epigenetics, structural genomics consortium (sgc) |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus : Q92831 |
| Total number of polymer chains | 2 |
| Total formula weight | 29045.47 |
| Authors | Chaikuad, A.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2015-12-16, release date: 2016-01-13, Last modification date: 2024-01-10) |
| Primary citation | Chaikuad, A.,Lang, S.,Brennan, P.E.,Temperini, C.,Fedorov, O.,Hollander, J.,Nachane, R.,Abell, C.,Muller, S.,Siegal, G.,Knapp, S. Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain. J.Med.Chem., 59:1648-1653, 2016 Cited by PubMed: 26731131DOI: 10.1021/acs.jmedchem.5b01719 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.12 Å) |
Structure validation
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