5FCT
Mouse thymidylate synthase in ternary complex with FdUMP and methylenetetrahydrofolate.
Summary for 5FCT
| Entry DOI | 10.2210/pdb5fct/pdb |
| Related | 3IHI 4E50 4EB4 4EIN 4EZ8 |
| Descriptor | Thymidylate synthase, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, ... (4 entities in total) |
| Functional Keywords | complex, enzyme, inhibitor, cofactor, transferase |
| Biological source | Mus musculus (House Mouse) |
| Total number of polymer chains | 2 |
| Total formula weight | 71573.29 |
| Authors | Dowiercial, A.,Wilk, P.,Jarmula, A.,Rode, W. (deposition date: 2015-12-15, release date: 2016-10-26, Last modification date: 2024-01-10) |
| Primary citation | Dowiercial, A.,Jarmula, A.,Wilk, P.,Rypniewski, W.,Kowalska, M.,Fraczyk, T.,Ciesla, J.,Rode, W. Mouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme Struct Chem, 2016 Cited by DOI: 10.1007/s11224-016-0840-8PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
Download full validation report
