5FAE
N184K pathological variant of gelsolin domain 2 (trigonal form)
Summary for 5FAE
| Entry DOI | 10.2210/pdb5fae/pdb |
| Related | 1KCQ |
| Descriptor | Gelsolin, CALCIUM ION, SULFATE ION, ... (6 entities in total) |
| Functional Keywords | gelsolin, amyloidosis, calcium, mutation, structural protein |
| Biological source | Homo sapiens (Human) |
| Cellular location | Isoform 2: Cytoplasm, cytoskeleton. Isoform 1: Secreted: P06396 |
| Total number of polymer chains | 1 |
| Total formula weight | 13747.63 |
| Authors | Boni, F.,Milani, M.,Ricagno, S.,Bolognesi, M.,de Rosa, M. (deposition date: 2015-12-11, release date: 2016-10-05, Last modification date: 2024-01-10) |
| Primary citation | Boni, F.,Milani, M.,Porcari, R.,Barbiroli, A.,Ricagno, S.,de Rosa, M. Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant. Sci Rep, 6:33463-33463, 2016 Cited by PubMed: 27633054DOI: 10.1038/srep33463 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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