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5F6J

Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque in Complex with HIV-1 gp120 Core

Summary for 5F6J
Entry DOI10.2210/pdb5f6j/pdb
DescriptorENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C, DH427 Antibody Light Chain, DH427 Antibody Heavy Chain (3 entities in total)
Functional Keywordsfab fragment, hiv-1, antibody, viral protein-immue system complex, viral protein/immue system
Biological sourceHuman immunodeficiency virus 1
More
Total number of polymer chains6
Total formula weight172529.24
Authors
Fera, D.,Harrison, S.C. (deposition date: 2015-12-06, release date: 2016-01-13, Last modification date: 2023-09-27)
Primary citationBradley, T.,Fera, D.,Bhiman, J.,Eslamizar, L.,Lu, X.,Anasti, K.,Zhang, R.,Sutherland, L.L.,Scearce, R.M.,Bowman, C.M.,Stolarchuk, C.,Lloyd, K.E.,Parks, R.,Eaton, A.,Foulger, A.,Nie, X.,Karim, S.S.,Barnett, S.,Kelsoe, G.,Kepler, T.B.,Alam, S.M.,Montefiori, D.C.,Moody, M.A.,Liao, H.X.,Morris, L.,Santra, S.,Harrison, S.C.,Haynes, B.F.
Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.
Cell Rep, 14:43-54, 2016
Cited by
PubMed: 26725118
DOI: 10.1016/j.celrep.2015.12.017
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (6.63 Å)
Structure validation

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