5F3F

Crystal structure of para-biphenyl-2-methyl-3'-methyl amide mannoside bound to FimH lectin domain

Summary for 5F3F

• Entry DOI: 10.2210/pdb5f3f/pdb
• Related: 5F2F
• Descriptor: Protein FimH, 3-[4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-methyl-phenyl]-~{N}-methyl-benzamide (3 entities in total)
• Functional Keywords: mannoside, fimh, adhesin, carbohydrate binding protein, sugar binding protein
• Biological source: Escherichia coli J96
• Cellular location: Fimbrium: P08191
• Total number of polymer chains: 1
• Total formula weight: 17320.25

Authors

Klein, R.D.,Hultgren, S.J. (deposition date: 2015-12-02, release date: 2016-12-07, Last modification date: 2024-01-03)

• Primary citation: Mydock-McGrane, L.,Cusumano, Z.,Han, Z.,Binkley, J.,Kostakioti, M.,Hannan, T.,Pinkner, J.S.,Klein, R.,Kalas, V.,Crowley, J.,Rath, N.P.,Hultgren, S.J.,Janetka, J.W.; Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections.; J.Med.Chem., 59:9390-9408, 2016; PubMed: 27689912; DOI: 10.1021/acs.jmedchem.6b00948

Experimental method

X-RAY DIFFRACTION (1.76 Å)