5F36

Crystal structure of the bromodomain of human ATAD2 in complex with Compound A12

Summary for 5F36

• Entry DOI: 10.2210/pdb5f36/pdb
• Descriptor: ATPase family AAA domain-containing protein 2, [(2~{R})-1-[(4-ethanoyl-1,3-thiazol-2-yl)amino]-1-oxidanylidene-propan-2-yl]azanium, SULFATE ION, ... (5 entities in total)
• Functional Keywords: hydrolase inhibitor complex, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15799.29

Authors

Dong, J.,Caflisch, A. (deposition date: 2015-12-02, release date: 2016-12-14, Last modification date: 2024-01-10)

• Primary citation: Dolbois, A.,Batiste, L.,Wiedmer, L.,Dong, J.,Brutsch, M.,Huang, D.,Deerain, N.M.,Spiliotopoulos, D.,Cheng-Sanchez, I.,Laul, E.,Nevado, C.,Sledz, P.,Caflisch, A.; Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers.; Acs Med.Chem.Lett., 11:1573-1580, 2020; PubMed: 32832026; DOI: 10.1021/acsmedchemlett.0c00080

Experimental method

X-RAY DIFFRACTION (1.5 Å)