5EZV

X-ray crystal structure of AMP-activated protein kinase alpha-2/alpha-1 RIM chimaera (alpha-2(1-347)/alpha-1(349-401)/alpha-2(397-end) beta-1 gamma-1) co-crystallized with C2 (5-(5-hydroxyl-isoxazol-3-yl)-furan-2-phosphonic acid)

Summary for 5EZV

• Entry DOI: 10.2210/pdb5ezv/pdb
• Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-2/alpha-1 RIM SWAP chimera, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (7 entities in total)
• Functional Keywords: transferase, serine/threonine kinase, allosteric activation, nucleotide-binding
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : P54646
• Total number of polymer chains: 6
• Total formula weight: 267844.05

Authors

Langendorf, C.G.,Kemp, B.E. (deposition date: 2015-11-26, release date: 2016-03-09, Last modification date: 2023-09-27)

• Primary citation: Langendorf, C.G.,Ngoei, K.R.,Scott, J.W.,Ling, N.X.,Issa, S.M.,Gorman, M.A.,Parker, M.W.,Sakamoto, K.,Oakhill, J.S.,Kemp, B.E.; Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.; Nat Commun, 7:10912-10912, 2016; PubMed: 26952388; DOI: 10.1038/ncomms10912

Experimental method

X-RAY DIFFRACTION (2.99 Å)