5EYK

CRYSTAL STRUCTURE OF AURORA B IN COMPLEX WITH BI 847325

Summary for 5EYK

Entry DOI	10.2210/pdb5eyk/pdb
Descriptor	Aurora kinase B-A, Inner centromere protein A, 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide, ... (4 entities in total)
Functional Keywords	kinase, inhibitor, transferase
Biological source	Xenopus laevis (African clawed frog) More
Cellular location	Nucleus: Q6DE08 O13024
Total number of polymer chains	4
Total formula weight	80509.32
Authors	Bader, G.,Zoephel, A. (deposition date: 2015-11-25, release date: 2016-08-17, Last modification date: 2016-10-19)
Primary citation	Sini, P.,Gurtler, U.,Zahn, S.K.,Baumann, C.,Rudolph, D.,Baumgartinger, R.,Strauss, E.,Haslinger, C.,Tontsch-Grunt, U.,Waizenegger, I.C.,Solca, F.,Bader, G.,Zoephel, A.,Treu, M.,Reiser, U.,Garin-Chesa, P.,Boehmelt, G.,Kraut, N.,Quant, J.,Adolf, G.R. Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases. Mol.Cancer Ther., 15:2388-2398, 2016 Cited by PubMed: 27496137 DOI: 10.1158/1535-7163.MCT-16-0066 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation