5EW2

Human thrombin sandwiched between two DNA aptamers: HD22 and HD1-deltaT12

Summary for 5EW2

• Entry DOI: 10.2210/pdb5ew2/pdb
• Related PRD ID: PRD_000020
• Descriptor: thrombin light chain, Thrombin heavy chain, HD22 (27mer), ... (8 entities in total)
• Functional Keywords: protein-dna complex, blood coagulation, dna aptamer, dna-inhibitor, g-quadruplex, duplex-quadruplex junction, serine protease, hydrolase, abasic furan, hydrolase-dna complex, protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 47725.30

Authors

Pica, A.,Russo Krauss, I.,Parente, V.,Sica, F. (deposition date: 2015-11-20, release date: 2016-11-30, Last modification date: 2020-07-29)

• Primary citation: Pica, A.,Russo Krauss, I.,Parente, V.,Tateishi-Karimata, H.,Nagatoishi, S.,Tsumoto, K.,Sugimoto, N.,Sica, F.; Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers.; Nucleic Acids Res., 45:461-469, 2017; PubMed: 27899589; DOI: 10.1093/nar/gkw1113

Experimental method

X-RAY DIFFRACTION (3.59 Å)