5EUA

Crystal structure of extended-spectrum beta-lactamase BEL-1 in complex with Moxalactam

Replaces:  4MXH

Summary for 5EUA

• Entry DOI: 10.2210/pdb5eua/pdb
• Related: 5EOE 5EOO 5EPH
• Descriptor: Beta-lactamase, (2R)-2-[(1R)-1-{[(2R)-2-carboxy-2-(4-hydroxyphenyl)acetyl]amino}-1-methoxy-2-oxoethyl]-5-methylidene-5,6-dihydro-2H-1,3 -oxazine-4-carboxylic acid, SODIUM ION, ... (4 entities in total)
• Functional Keywords: hydrolase-antibiotic complex, extended-spectrum beta-lactamase, pseudomonas aeruginosa, oxacephem antibiotic, hydrolase/antibiotic
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 58702.05

Authors

Pozzi, C.,De Luca, F.,Benvenuti, M.,Docquier, J.D.,Mangani, S. (deposition date: 2015-11-18, release date: 2016-09-21, Last modification date: 2024-01-10)

• Primary citation: Pozzi, C.,De Luca, F.,Benvenuti, M.,Poirel, L.,Nordmann, P.,Rossolini, G.M.,Mangani, S.,Docquier, J.D.; Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum beta-Lactamase and Its Complexes with Moxalactam and Imipenem.; Antimicrob.Agents Chemother., 60:7189-7199, 2016; PubMed: 27671060; DOI: 10.1128/AAC.00936-16

Experimental method

X-RAY DIFFRACTION (1.85 Å)