5EQG

Human GLUT1 in complex with inhibitor (2~{S})-3-(4-fluorophenyl)-2-[2-(3-hydroxyphenyl)ethanoylamino]-~{N}-[(1~{S})-1-phenylethyl]propanamide

Summary for 5EQG

Entry DOI	10.2210/pdb5eqg/pdb
Related	4PYP 5EQH 5EQI
Descriptor	Solute carrier family 2, facilitated glucose transporter member 1, (2~{S})-3-(4-fluorophenyl)-2-[2-(3-hydroxyphenyl)ethanoylamino]-~{N}-[(1~{S})-1-phenylethyl]propanamide (2 entities in total)
Functional Keywords	mfs transporter, glucose transporter, transport protein-inhibitor complex, transport protein/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	54545.87
Authors	Kapoor, K.,Finer-Moore, J.,Pedersen, B.P.,Caboni, L.,Waight, A.B.,Hillig, R.,Bringmann, P.,Heisler, I.,Muller, T.,Siebeneicher, H.,Stroud, R.M. (deposition date: 2015-11-12, release date: 2016-04-13, Last modification date: 2023-09-27)
Primary citation	Kapoor, K.,Finer-Moore, J.S.,Pedersen, B.P.,Caboni, L.,Waight, A.,Hillig, R.C.,Bringmann, P.,Heisler, I.,Muller, T.,Siebeneicher, H.,Stroud, R.M. Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides. Proc.Natl.Acad.Sci.USA, 113:4711-4716, 2016 Cited by PubMed: 27078104 DOI: 10.1073/pnas.1603735113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation