5ELU

Isoform-specific inhibition of SUMO-dependent protein-protein interactions

Summary for 5ELU

Entry DOI	10.2210/pdb5elu/pdb
Descriptor	SUMO-Affirmer-S2B3, Small ubiquitin-related modifier 2, SULFATE ION, ... (4 entities in total)
Functional Keywords	ubiquitin, sumoylation, signaling protein
Biological source	synthetic construct More
Cellular location	Nucleus: P61956
Total number of polymer chains	2
Total formula weight	22762.71
Authors	Hughes, D.J.,Tiede, C.,Hall, N.,Tang, A.A.S.,Trinh, C.H.,Zajac, K.,Mandal, U.,Howell, G.,Edwards, T.A.,McPherson, M.J.,Tomlinson, D.C.,Whitehouse, A. (deposition date: 2015-11-05, release date: 2016-11-16, Last modification date: 2024-01-10)
Primary citation	Hughes, D.J.,Tiede, C.,Penswick, N.,Tang, A.A.,Trinh, C.H.,Mandal, U.,Zajac, K.Z.,Gaule, T.,Howell, G.,Edwards, T.A.,Duan, J.,Feyfant, E.,McPherson, M.J.,Tomlinson, D.C.,Whitehouse, A. Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology. Sci Signal, 10:-, 2017 Cited by PubMed: 29138295 DOI: 10.1126/scisignal.aaj2005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation