5EKX

DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYLMETHIONINE AND FRAGMENT NB2E11

Summary for 5EKX

• Entry DOI: 10.2210/pdb5ekx/pdb
• Descriptor: NS5 METHYLTRANSFERASE, S-ADENOSYLMETHIONINE, 4-chloro-5-methylbenzene-1,2-diamine, ... (4 entities in total)
• Functional Keywords: ns5 methyltransferase dengue virus, fragment-based drug design, transferase
• Biological source: Dengue virus type 3 (strain Philippines/H87/1956) (DENV-3)
• Cellular location: Protein C: Virion . Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted . Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P27915
• Total number of polymer chains: 2
• Total formula weight: 63367.11

Authors

Barral, K.,Bricogne, G.,Sharff, A. (deposition date: 2015-11-04, release date: 2016-10-26, Last modification date: 2024-01-10)

• Primary citation: Benmansour, F.,Trist, I.,Coutard, B.,Decroly, E.,Querat, G.,Brancale, A.,Barral, K.; Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.; Eur.J.Med.Chem., 125:865-880, 2016; PubMed: 27750202; DOI: 10.1016/j.ejmech.2016.10.007

Experimental method

X-RAY DIFFRACTION (1.76 Å)