5EJV

RORy in complex with T090131718 and Coactivator peptide EBI96

Summary for 5EJV

Entry DOI	10.2210/pdb5ejv/pdb
Descriptor	Nuclear receptor ROR-gamma, EBI96 Coactivator Peptide, N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE, ... (4 entities in total)
Functional Keywords	rorgamma, t090131718, coactivator peptide, transcription
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus : P51449
Total number of polymer chains	4
Total formula weight	65673.18
Authors	Marcotte, D.M. (deposition date: 2015-11-02, release date: 2016-04-27, Last modification date: 2023-09-27)
Primary citation	Enyedy, I.J.,Powell, N.A.,Caravella, J.,van Vloten, K.,Chao, J.,Banerjee, D.,Marcotte, D.,Silvian, L.,McKenzie, A.,Hong, V.S.,Fontenot, J.D. Discovery of biaryls as ROR gamma inverse agonists by using structure-based design. Bioorg.Med.Chem.Lett., 26:2459-2463, 2016 Cited by PubMed: 27080181 DOI: 10.1016/j.bmcl.2016.03.109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.58 Å)

Structure validation