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5EIR

Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.

Summary for 5EIR
Entry DOI10.2210/pdb5eir/pdb
Related2V8W 2W97
DescriptorEukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4 gamma 1, ~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-6-oxidanylidene-7-(phenylmethyl)-1~{H}-purin-7-ium-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-1,1,1-tris(fluoranyl)methanesulfonamide, ... (5 entities in total)
Functional Keywordscomplex, inhibitor, translation, eif4e
Biological sourceHomo sapiens (Human)
More
Cellular locationCytoplasm, P-body : P06730
Total number of polymer chains2
Total formula weight27582.91
Authors
Nowicki, M.W.,Walkinshaw, M.D.,Fischer, P.M. (deposition date: 2015-10-30, release date: 2016-09-07, Last modification date: 2024-01-10)
Primary citationSoukarieh, F.,Nowicki, M.W.,Bastide, A.,Poyry, T.,Jones, C.,Dudek, K.,Patwardhan, G.,Meullenet, F.,Oldham, N.J.,Walkinshaw, M.D.,Willis, A.E.,Fischer, P.M.
Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation.
Eur.J.Med.Chem., 124:200-217, 2016
Cited by
PubMed: 27592390
DOI: 10.1016/j.ejmech.2016.08.047
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.69 Å)
Structure validation

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