5EF6

Structure of HOXB13 complex with methylated DNA

Summary for 5EF6

• Entry DOI: 10.2210/pdb5ef6/pdb
• Descriptor: Homeobox protein Hox-B13, DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*GP*TP*CP*C)-3'), DNA (5'-D(P*GP*GP*AP*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), ... (4 entities in total)
• Functional Keywords: transcription factor, methylated dna, complex, transcription
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: Q92826
• Total number of polymer chains: 12
• Total formula weight: 74280.46

Authors

Morgunova, E.,Yin, Y.,Jolma, A.,Popov, A.,Taipale, J. (deposition date: 2015-10-23, release date: 2017-02-08, Last modification date: 2024-01-10)

• Primary citation: Yin, Y.,Morgunova, E.,Jolma, A.,Kaasinen, E.,Sahu, B.,Khund-Sayeed, S.,Das, P.K.,Kivioja, T.,Dave, K.,Zhong, F.,Nitta, K.R.,Taipale, M.,Popov, A.,Ginno, P.A.,Domcke, S.,Yan, J.,Schubeler, D.,Vinson, C.,Taipale, J.; Impact of cytosine methylation on DNA binding specificities of human transcription factors.; Science, 356:-, 2017; PubMed: 28473536; DOI: 10.1126/science.aaj2239

Experimental method

X-RAY DIFFRACTION (3 Å)