5EBK

Trypanothione reductase in complex with 6-(sec-butoxy)-2-((3-chlorophenyl)thio)pyrimidin-4-amine

Summary for 5EBK

• Entry DOI: 10.2210/pdb5ebk/pdb
• Related: 2jk6
• Descriptor: Trypanothione reductase, FLAVIN-ADENINE DINUCLEOTIDE, 6-sec-Butoxy-2-[(3-chlorophenyl)sulfanyl]-4-pyrimidinamine, ... (4 entities in total)
• Functional Keywords: oxidoreductase
• Biological source: Leishmania infantum
• Total number of polymer chains: 2
• Total formula weight: 114350.96

Authors

Ilari, A.,Angiulli, G. (deposition date: 2015-10-19, release date: 2016-10-26, Last modification date: 2024-01-10)

• Primary citation: Saccoliti, F.,Angiulli, G.,Pupo, G.,Pescatori, L.,Madia, V.N.,Messore, A.,Colotti, G.,Fiorillo, A.,Scipione, L.,Gramiccia, M.,Di Muccio, T.,Di Santo, R.,Costi, R.,Ilari, A.; Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives.; J Enzyme Inhib Med Chem, 32:304-310, 2017; PubMed: 28098499; DOI: 10.1080/14756366.2016.1250755

Experimental method

X-RAY DIFFRACTION (3.51 Å)