5EA6

Crystal Structure of Inhibitor BTA-9881 in Complex with Prefusion RSV F Glycoprotein

Summary for 5EA6

Entry DOI	10.2210/pdb5ea6/pdb
Related	4MMU 5EA3 5EA4 5EA5 5EA7 5EA8
Descriptor	Fusion glycoprotein F0, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, SULFATE ION, ... (5 entities in total)
Functional Keywords	class i viral fusion protein, fusion, respiratory syncytial virus, prefusion, viral protein, fusion inhibitor, cell invasion-inhibitor complex, cell invasion/inhibitor
Biological source	Human respiratory syncytial virus A (strain A2)
Total number of polymer chains	1
Total formula weight	64200.71
Authors	Battles, M.B.,McLellan, J.S.,Arnoult, E.,Roymans, D.,Langedijk, J.P. (deposition date: 2015-10-15, release date: 2015-12-09, Last modification date: 2023-09-27)
Primary citation	Battles, M.B.,Langedijk, J.P.,Furmanova-Hollenstein, P.,Chaiwatpongsakorn, S.,Costello, H.M.,Kwanten, L.,Vranckx, L.,Vink, P.,Jaensch, S.,Jonckers, T.H.,Koul, A.,Arnoult, E.,Peeples, M.E.,Roymans, D.,McLellan, J.S. Molecular mechanism of respiratory syncytial virus fusion inhibitors. Nat.Chem.Biol., 12:87-93, 2016 Cited by PubMed: 26641933 DOI: 10.1038/nchembio.1982 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation