5E9C

Crystal structure of human heparanase in complex with heparin tetrasaccharide dp4

Summary for 5E9C

Entry DOI	10.2210/pdb5e9c/pdb
Descriptor	Heparanase, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	glycoside hydrolase, ligand 4, protein, sugar, hydrolase
Biological source	Homo sapiens (Human) More
Cellular location	Lysosome membrane; Peripheral membrane protein: Q9Y251 Q9Y251
Total number of polymer chains	2
Total formula weight	54146.11
Authors	Wu, L.,Davies, G.J. (deposition date: 2015-10-15, release date: 2015-11-18, Last modification date: 2024-01-10)
Primary citation	Wu, L.,Viola, C.M.,Brzozowski, A.M.,Davies, G.J. Structural characterization of human heparanase reveals insights into substrate recognition. Nat.Struct.Mol.Biol., 22:1016-1022, 2015 Cited by PubMed: 26575439 DOI: 10.1038/nsmb.3136 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation