5E88

Crystal structure of Human galectin-3 CRD in complex with thienyl-1,2,3-triazolyl thiodigalactoside inhibitor

5E88 の概要

• エントリーDOI: 10.2210/pdb5e88/pdb
• 関連するPDBエントリー: 5E89 5E8A
• 分子名称: Galectin-3, CHLORIDE ION, 3-deoxy-3-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-1-thio-3-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranoside, ... (4 entities in total)
• 機能のキーワード: carbohydrate-recognition, beta sandwich, carbohydrate binding protein, sugar binding protein, sugar binding protein-inhibitor complex, sugar binding protein/inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P17931
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16418.26

構造登録者

Collins, P.M.,Blanchard, H. (登録日: 2015-10-13, 公開日: 2016-08-24, 最終更新日: 2023-09-27)

• 主引用文献: Delaine, T.,Collins, P.,MacKinnon, A.,Sharma, G.,Stegmayr, J.,Rajput, V.K.,Mandal, S.,Cumpstey, I.,Larumbe, A.,Salameh, B.A.,Kahl-Knutsson, B.,van Hattum, H.,van Scherpenzeel, M.,Pieters, R.J.,Sethi, T.,Schambye, H.,Oredsson, S.,Leffler, H.,Blanchard, H.,Nilsson, U.J.; Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition.; Chembiochem, 17:1759-1770, 2016; PubMed: 27356186; DOI: 10.1002/cbic.201600285

実験手法

X-RAY DIFFRACTION (1.6 Å)