5E1E

Human JAK1 kinase in complex with compound 30 at 2.30 Angstroms resolution

Summary for 5E1E

• Entry DOI: 10.2210/pdb5e1e/pdb
• Descriptor: Tyrosine-protein kinase JAK1, DI(HYDROXYETHYL)ETHER, 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-N-(piperidin-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-amine, ... (4 entities in total)
• Functional Keywords: kinase, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Endomembrane system; Peripheral membrane protein: P23458
• Total number of polymer chains: 2
• Total formula weight: 67924.29

Authors

Ferguson, A.D. (deposition date: 2015-09-29, release date: 2015-11-25, Last modification date: 2015-12-30)

• Primary citation: Vasbinder, M.M.,Alimzhanov, M.,Augustin, M.,Bebernitz, G.,Bell, K.,Chuaqui, C.,Deegan, T.,Ferguson, A.D.,Goodwin, K.,Huszar, D.,Kawatkar, A.,Kawatkar, S.,Read, J.,Shi, J.,Steinbacher, S.,Steuber, H.,Su, Q.,Toader, D.,Wang, H.,Woessner, R.,Wu, A.,Ye, M.,Zinda, M.; Identification of azabenzimidazoles as potent JAK1 selective inhibitors.; Bioorg.Med.Chem.Lett., 26:60-67, 2016; PubMed: 26614408; DOI: 10.1016/j.bmcl.2015.11.031

Experimental method

X-RAY DIFFRACTION (2.3 Å)