5DZL

Crystal structure of the protein human CEACAM1

Replaces:  4QYC

Summary for 5DZL

• Entry DOI: 10.2210/pdb5dzl/pdb
• Related: 4QXW
• Descriptor: Carcinoembryonic antigen-related cell adhesion molecule 1 (1 entity in total)
• Functional Keywords: cell adhesion
• Biological source: Homo sapiens (Human)
• Cellular location: Isoform 1: Cell membrane ; Single-pass type I membrane protein . Isoform 2: Secreted . Isoform 3: Secreted . Isoform 4: Secreted . Isoform 5: Cell membrane; Single-pass type I membrane protein. Isoform 6: Cell membrane; Single-pass type I membrane protein. Isoform 7: Cell membrane; Single-pass type I membrane protein. Isoform 8: Cell membrane ; Single-pass type I membrane protein . Cell projection, microvillus membrane ; Single-pass type I membrane protein : P13688
• Total number of polymer chains: 4
• Total formula weight: 47945.00

Authors

Huang, Y.H.,Russell, A.,Gandhi, A.K.,Kondo, Y.,Chen, Q.,Petsko, G.A.,Blumberg, R.S. (deposition date: 2015-09-25, release date: 2015-10-07, Last modification date: 2023-09-27)

• Primary citation: Huang, Y.H.,Zhu, C.,Kondo, Y.,Anderson, A.C.,Gandhi, A.,Russell, A.,Dougan, S.K.,Petersen, B.S.,Melum, E.,Pertel, T.,Clayton, K.L.,Raab, M.,Chen, Q.,Beauchemin, N.,Yazaki, P.J.,Pyzik, M.,Ostrowski, M.A.,Glickman, J.N.,Rudd, C.E.,Ploegh, H.L.,Franke, A.,Petsko, G.A.,Kuchroo, V.K.,Blumberg, R.S.; CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.; Nature, 517:386-390, 2015; PubMed: 25363763; DOI: 10.1038/nature13848

Experimental method

X-RAY DIFFRACTION (3.4006 Å)