5DYY
Crystal structure of human butyrylcholinesterase in complex with N-((1-benzylpiperidin-3-yl)methyl)naphthalene-2-sulfonamide
Summary for 5DYY
Entry DOI | 10.2210/pdb5dyy/pdb |
Descriptor | Cholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total) |
Functional Keywords | hydrolase, human butyrylcholinesterase ad alzheimer disease sulfonamide |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 125771.11 |
Authors | Coquelle, N.,Brus, B.,Colletier, J.P. (deposition date: 2015-09-25, release date: 2017-01-18, Last modification date: 2020-07-29) |
Primary citation | Kosak, U.,Brus, B.,Knez, D.,Sink, R.,Zakelj, S.,Trontelj, J.,Pislar, A.,Slenc, J.,Gobec, M.,Zivin, M.,Tratnjek, L.,Perse, M.,Saat, K.,Podkowa, A.,Filipek, B.,Nachon, F.,Brazzolotto, X.,Wieckowska, A.,Malawska, B.,Stojan, J.,Rascan, I.M.,Kos, J.,Coquelle, N.,Colletier, J.P.,Gobec, S. Development of an in-vivo active reversible butyrylcholinesterase inhibitor. Sci Rep, 6:39495-39495, 2016 Cited by PubMed: 28000737DOI: 10.1038/srep39495 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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