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5DXB

Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P1 and Estradiol

Summary for 5DXB
Entry DOI10.2210/pdb5dxb/pdb
DescriptorEstrogen receptor, Nuclear receptor coactivator 2, ESTRADIOL, ... (7 entities in total)
Functional Keywordsestrogen receptor alpha, somatic mutataion, stapled peptide, peptide mimetic, hormone receptor, breast cancer, hormone receptor-peptide complex, hormone receptor/peptide
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight63218.21
Authors
Fanning, S.W.,Speltz, T.E.,Mayne, C.G.,Tajkhorshid, E.,Greene, G.L.,Moore, T.W. (deposition date: 2015-09-23, release date: 2016-07-27, Last modification date: 2020-02-19)
Primary citationSpeltz, T.E.,Fanning, S.W.,Mayne, C.G.,Fowler, C.,Tajkhorshid, E.,Greene, G.L.,Moore, T.W.
Stapled Peptides with gamma-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.
Angew. Chem. Int. Ed. Engl., 55:4252-4255, 2016
Cited by
PubMed: 26928945
DOI: 10.1002/anie.201510557
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.08 Å)
Structure validation

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