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5DQO

Crystal structure of Y347F mutant of human primase p58 iron-sulfur cluster domain

Summary for 5DQO
Entry DOI10.2210/pdb5dqo/pdb
Related3L9Q
DescriptorDNA primase large subunit, IRON/SULFUR CLUSTER (3 entities in total)
Functional Keywordsiron-sulfur cluster, dna priming, replication
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight92030.36
Authors
Salay, L.E.,Thompson, M.K.,Chazin, W.J. (deposition date: 2015-09-15, release date: 2016-09-21, Last modification date: 2023-09-27)
Primary citationO'Brien, E.,Holt, M.E.,Thompson, M.K.,Salay, L.E.,Ehlinger, A.C.,Chazin, W.J.,Barton, J.K.
The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport.
Science, 355:-, 2017
Cited by
PubMed: 28232525
DOI: 10.1126/science.aag1789
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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