5DOT

Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), apo form

Summary for 5DOT

• Entry DOI: 10.2210/pdb5dot/pdb
• Descriptor: Carbamoyl-phosphate synthase [ammonia], mitochondrial, NICKEL (II) ION, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: carbamoyl phosphate synthase (ammonia utilizing), carbamoyl phosphate, ammonia, n-acetyl-l-glutamate, adenosine triphosphate, apo, urea cycle, ligase, multi-domain, allosteric site, rare disease, cps1 deficiency, hyperammonemia
• Biological source: Homo sapiens (Human)
• Cellular location: Mitochondrion : P31327
• Total number of polymer chains: 2
• Total formula weight: 328919.70

Authors

Polo, L.M.,de Cima, S.,Fita, I.,Rubio, V. (deposition date: 2015-09-11, release date: 2015-12-09, Last modification date: 2024-01-10)

• Primary citation: de Cima, S.,Polo, L.M.,Diez-Fernandez, C.,Martinez, A.I.,Cervera, J.,Fita, I.,Rubio, V.; Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis.; Sci Rep, 5:16950-16950, 2015; PubMed: 26592762; DOI: 10.1038/srep16950

Experimental method

X-RAY DIFFRACTION (2.4 Å)