5V3P

Human A20 OTU domain (I325N) with acetamidylated C103

Replaces:  4ZRHReplaces:  5DOD

Summary for 5V3P

• Entry DOI: 10.2210/pdb5v3p/pdb
• Related: 5V3B
• Descriptor: Tumor necrosis factor alpha-induced protein 3 (2 entities in total)
• Functional Keywords: otu domain, acetamidylation, ubiquitin editing, hydrolase, ligase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 258968.86

Authors

Langley, D.B.,Christ, D.,Grey, S. (deposition date: 2017-03-07, release date: 2018-03-21, Last modification date: 2023-10-04)

• Primary citation: Zammit, N.W.,Siggs, O.M.,Gray, P.E.,Horikawa, K.,Langley, D.B.,Walters, S.N.,Daley, S.R.,Loetsch, C.,Warren, J.,Yap, J.Y.,Cultrone, D.,Russell, A.,Malle, E.K.,Villanueva, J.E.,Cowley, M.J.,Gayevskiy, V.,Dinger, M.E.,Brink, R.,Zahra, D.,Chaudhri, G.,Karupiah, G.,Whittle, B.,Roots, C.,Bertram, E.,Yamada, M.,Jeelall, Y.,Enders, A.,Clifton, B.E.,Mabbitt, P.D.,Jackson, C.J.,Watson, S.R.,Jenne, C.N.,Lanier, L.L.,Wiltshire, T.,Spitzer, M.H.,Nolan, G.P.,Schmitz, F.,Aderem, A.,Porebski, B.T.,Buckle, A.M.,Abbott, D.W.,Ziegler, J.B.,Craig, M.E.,Benitez-Aguirre, P.,Teo, J.,Tangye, S.G.,King, C.,Wong, M.,Cox, M.P.,Phung, W.,Tang, J.,Sandoval, W.,Wertz, I.E.,Christ, D.,Goodnow, C.C.,Grey, S.T.; Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.; Nat.Immunol., 20:1299-1310, 2019; PubMed: 31534238; DOI: 10.1038/s41590-019-0492-0

Experimental method

X-RAY DIFFRACTION (2.5 Å)