5DK3

Crystal Structure of Pembrolizumab, a full length IgG4 antibody

Summary for 5DK3

Entry DOI	10.2210/pdb5dk3/pdb
Related PRD ID	PRD_900003
Descriptor	Light Chain, Heavy Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	cancer, antibody, subclasses, igg4, melanoma, immune system
Biological source	Homo sapiens More
Total number of polymer chains	4
Total formula weight	149953.56
Authors	Scapin, G.,Prosise, W.,Reichert, P. (deposition date: 2015-09-02, release date: 2015-11-18, Last modification date: 2020-07-29)
Primary citation	Scapin, G.,Yang, X.,Prosise, W.W.,McCoy, M.,Reichert, P.,Johnston, J.M.,Kashi, R.S.,Strickland, C. Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab. Nat.Struct.Mol.Biol., 22:953-958, 2015 Cited by PubMed: 26595420 DOI: 10.1038/nsmb.3129 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation