5DJP

Crystal structure of human FPPS in complex with biaryl compound 5

Summary for 5DJP

Entry DOI	10.2210/pdb5djp/pdb
Related	5DGN 5DIQ
Descriptor	Farnesyl pyrophosphate synthase, 4-(naphthalen-1-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	transferase, isoprene biosynthesis, cholesterol biosynthesis
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P14324
Total number of polymer chains	1
Total formula weight	40566.14
Authors	Rondeau, J.M.,Bourgier, E.,Lehmann, S. (deposition date: 2015-09-02, release date: 2015-09-30, Last modification date: 2015-11-04)
Primary citation	Marzinzik, A.L.,Amstutz, R.,Bold, G.,Bourgier, E.,Cotesta, S.,Glickman, J.F.,Gotte, M.,Henry, C.,Lehmann, S.,Hartwieg, J.C.,Ofner, S.,Pelle, X.,Roddy, T.P.,Rondeau, J.M.,Stauffer, F.,Stout, S.J.,Widmer, A.,Zimmermann, J.,Zoller, T.,Jahnke, W. Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10:1884-1891, 2015 Cited by PubMed: 26381451 DOI: 10.1002/cmdc.201500338 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation